The Rune of Ascendance gives the player a chance to roll the dice and change one of their items to a unique one of the same kind. It may be difficult to assess what the best use case for the Rune of Ascendance is, but I’ll tackle and explain everything in this guide.

What is the best use for Rune of Ascendance in Last Epoch?

The best use case for the Rune of Ascendance is if you want to get a unique item that’s very difficult to find in the Monoliths. For example, theHerald of Scurryis a very rare item drop in The Black Sun monolith, but it’s the focal point of the Beastmaster Squirrel Build. you’re able to use the Rune of Ascendance to possiblytransform one of your helmetsinto a Herald of Scurry!

A big catch to the Rune of Ascendance is it has avery low chanceof crafting a legendary item. You can use aRunes of Ascendance Calculatorto simulate your chances of getting the item you want.

Image via Eleventh Hour Games

Currently, there is only one item that specifically requires the Rune of Ascendance, theFractured Crown.The Fractured Crown contains theSpell Critical Strike Chanceaffix, which is an essential part of increasing your output damage as a mage.

Related:Should you give Erza’s Ledger to Artem or Erza in Last Epoch?

Best use case scenarios for Rune of Ascendance in Last Epoch

With Last Epoch’s crazy amount offlexibility and build variety, it’s almost impossible to list down all ideal use cases for the Rune of Ascendance. Hopefully, the examples above gave you an idea of how you canoptimally use the Rune of Ascendance.

As a last bit of advice, before using the Rune of Ascendance,check your buildand make sure tosynergize your equipment implicitsand affixeswith your character’s specialty.

For more guides inLast Epoch, check outLast Epoch Monolith Guideright here at Pro Game Guides.